The recent controversy surrounding testosterone replacement therapy (TRT) is rapidly losing steam. The two studies that questioned the safety of TRT have been exposed as being flawed and misleading. Even the FDA has cited the studies’ significant flaws and weaknesses in their Rejection of Citizens Petition for More Stringent Warnings on Testosterone Products!
An article published in the October 2014 issue of Current Opinion in Endocrinology, Diabetes and Obesity titled Testosterone and Weight Loss: The Evidence, is an extensive literature review of recent data linking long-term TRT in overweight and obese men with low testosterone to increased lean body mass, decreased fat mass, improvement in overall body composition and sustained weight loss. Low testosterone is common in overweight middle-aged men.
Key points from the review were that long-term TRT:
- Improves body composition (reduces body fat and improves muscle mass)
- Produces sustained weight loss without recidivism (regaining the weight)
- Combined with lifestyle modifications produces even better results
- Even without lifestyle modifications, TRT may prove helpful in the management of obesity
- Improves all components of the metabolic syndrome (elevated blood pressure, high triglycerides, low HDL, elevated blood glucose, increased abdominal fat)
Additional quality of life benefits of TRT noted by the authors:
- Increased motivation and physical activity
- Reduced fatigue and increased energy
- Improved libido function and mood
In their conclusion, the authors state – “this therapy has been used over the past 7 decades to treat hypogonadism (low testosterone) and is proven to be well tolerated and effective.” That pretty much sums it up!